These tiny ruptures cannot be detected with traditional methods, but are clinically relevant as they can induce delivery, cause infections, and threaten the health of both mother and child.īecause Actim PROM is specific to amniotic fluid IGFBP-1, tests can be completed even in the presence of blood and other bodily fluids, infections, and medical products. Thanks to its high sensitivity, Actim PROM detects even low concentrations of IGFBP-1 caused by micro-ruptures in the fetal membrane. Actim PROM detects IGFBP-1 in vaginal swab samples and helps to identify membrane ruptures. Amniotic fluid is normally not found in the vagina, but when fetal membranes rupture, amniotic fluid leaks into the vagina and the IGFBP-1 concentration quickly rises and remains high until delivery. How Actim prom works Actim ® PROM and Vaginal IGFBP-1Īctim PROM rapid test is based on highly specific monoclonal antibodies that bind to the insulin-like growth factor binding protein-1 (IGFBP-1) present in amniotic fluid in high amounts. Prevention If you suspect your water has broken prematurely, a doctor or gynecologist can use a pH test, nitrazine test, and many others to diagnose you.
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